Bromocriptine inhibits release of which hormone?

Bromocriptine inhibits release of which hormone?

• A. Growth Hormone
• B. Prolactin
• C. Antidiuretic Hormone
• D. ACTH

Answer: (B)

Bromocriptine inhibits the release of prolactin. It acts as a dopamine D2 receptor agonist, binding to lactotrophs in the anterior pituitary and tonically suppressing prolactin synthesis and secretion. This is why bromocriptine is used to treat hyperprolactinemia, which can cause galactorrhea and infertility by elevating prolactin and suppressing GnRH. The other hormones aren’t primarily regulated by dopamine in this inhibitory way: growth hormone is controlled mainly by GHRH and somatostatin; antidiuretic hormone is released from the posterior pituitary in response to osmolality and volume status; ACTH is driven by CRH and cortisol feedback.

Bromocriptine inhibits the release of prolactin. It acts as a dopamine D2 receptor agonist, binding to lactotrophs in the anterior pituitary and tonically suppressing prolactin synthesis and secretion. This is why bromocriptine is used to treat hyperprolactinemia, which can cause galactorrhea and infertility by elevating prolactin and suppressing GnRH. The other hormones aren’t primarily regulated by dopamine in this inhibitory way: growth hormone is controlled mainly by GHRH and somatostatin; antidiuretic hormone is released from the posterior pituitary in response to osmolality and volume status; ACTH is driven by CRH and cortisol feedback.