In Simmonds cachexia, which sign is expected?

In Simmonds cachexia, which sign is expected?

• A. High body temperature
• B. Ruddy complexion
• C. Silky body hair
• D. Muscle wasting

Answer: (D)

Simmonds’ cachexia occurs with panhypopituitarism, where loss of pituitary hormones leaves the body in a severely catabolic state. Without growth hormone, thyroid axis support, and other anabolic signals, the body breaks down lean tissue to meet energy and metabolic needs, leading to progressive muscle wasting. Fever and rapid skin changes aren’t typical features of this endocrine wasting pattern, and hair texture isn’t a defining sign here. The hallmark sign you’d expect is clear muscle wasting from the loss of lean body mass.

Simmonds’ cachexia occurs with panhypopituitarism, where loss of pituitary hormones leaves the body in a severely catabolic state. Without growth hormone, thyroid axis support, and other anabolic signals, the body breaks down lean tissue to meet energy and metabolic needs, leading to progressive muscle wasting. Fever and rapid skin changes aren’t typical features of this endocrine wasting pattern, and hair texture isn’t a defining sign here. The hallmark sign you’d expect is clear muscle wasting from the loss of lean body mass.